Alcudacigib

Alcudacigib (Compound 9) is an inhibitor of DGKζ. Alcudacigib can be used for research in cancer related to immunocyte activation or cancer resistant to anti-PD-1 antibody/anti-PD-L1 antibody[1].

Product Specifications

CAS Number

[2660218-70-0]

Product Name Alternative

DGKζ-IN-1

UNSPSC

12352005

Target

DGK

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dgkζ-in-1.html

Solubility

10 mM in DMSO

Smiles

FC(F)(C1=C(N2C[C@@H](CCC2)CN)C(NC(C3=CSC(C4=CN=NC=C4)=N3)=O)=CC=C1OC5=CC=CC=C5)F

Molecular Formula

C27H25F3N6O2S

Molecular Weight

554.59

References & Citations

[1]Watanabe H, et al. Preparation of pyridazinyl-thiazolecarboxamide compound as DGKζ inhibitor. World Intellectual Property Organization, WO2021132422 A1. 2021-07-01.