COX-2-IN-32

COX-2-IN-32 (Compound 2f) is an iNOS and COX-2 inhibitor. COX-2-IN-32 decreases the expression of NF-κB. COX-2-IN-32 has anti-inflammatory activity by inhibits NO production in LPS-induced RAW264.7 macrophages (IC50: 11.2 μM) [1].

Product Specifications

CAS Number

[2725863-08-9]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

COX; NF-κB; NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cox-2-in-32.html

Solubility

10 mM in DMSO

Smiles

COC(C=C1)=CC=C1OC(C=C2)=CC=C2/C=C/C(C3=CC(OC)=C(C(OC)=C3)OC)=O

Molecular Formula

C25H24O6

Molecular Weight

420.45

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Emam SH, et al. Design and synthesis of methoxyphenyl- and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of NF-κB in LPS-induced RAW264.7 macrophage cells. Bioorg Chem. 2021 Feb;107:104630.