COX-2-IN-32
COX-2-IN-32 (Compound 2f) is an iNOS and COX-2 inhibitor. COX-2-IN-32 decreases the expression of NF-κB. COX-2-IN-32 has anti-inflammatory activity by inhibits NO production in LPS-induced RAW264.7 macrophages (IC50: 11.2 μM) [1].
Product Specifications
CAS Number
2725863-08-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
COX; NF-κB; NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-2-in-32.html
Solubility
10 mM in DMSO
Smiles
COC(C=C1)=CC=C1OC(C=C2)=CC=C2/C=C/C(C3=CC(OC)=C(C(OC)=C3)OC)=O
Molecular Formula
C25H24O6
Molecular Weight
420.45
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Emam SH, et al. Design and synthesis of methoxyphenyl- and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of NF-κB in LPS-induced RAW264.7 macrophage cells. Bioorg Chem. 2021 Feb;107:104630.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2
Available Sizes
Frequently Asked Questions
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