Protein kinase inhibitor 4

Protein kinase inhibitor 4 (Compound 3) is a protein kinase inhibitor that inhibits TRK-A and ROS1 (IC50=3.0 nM and 104 nM respectively) [1].

Product Specifications

CAS Number

[2278205-04-0]

UNSPSC

12352005

Target

ROS Kinase; Trk Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protein-kinase-inhibitor-4.html

Solubility

10 mM in DMSO

Smiles

FC1=C(C=C(C=C1)F)[C@@H]2N(C3=NC4=C(C=NN4C=C3)NC(C5=CC=C(C=C5)NS(CC)(=O)=O)=O)CCC2

Molecular Formula

C25H24F2N6O3S

Molecular Weight

526.56

References & Citations

[1]Dawei Zhang, et al. Substituted pyrazolopyrimidines useful as kinases inhibitors. Patent. WO2019029629A1.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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