Protein kinase inhibitor 4
Protein kinase inhibitor 4 (Compound 3) is a protein kinase inhibitor that inhibits TRK-A and ROS1 (IC50=3.0 nM and 104 nM respectively) [1].
Product Specifications
CAS Number
[2278205-04-0]
UNSPSC
12352005
Target
ROS Kinase; Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protein-kinase-inhibitor-4.html
Solubility
10 mM in DMSO
Smiles
FC1=C(C=C(C=C1)F)[C@@H]2N(C3=NC4=C(C=NN4C=C3)NC(C5=CC=C(C=C5)NS(CC)(=O)=O)=O)CCC2
Molecular Formula
C25H24F2N6O3S
Molecular Weight
526.56
References & Citations
[1]Dawei Zhang, et al. Substituted pyrazolopyrimidines useful as kinases inhibitors. Patent. WO2019029629A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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