Forskolin (GMP)
Product Specifications
UNSPSC Description
Forskolin (Coleonol) (GMP) is Forskolin (HY-15371) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Forskolin is a potent adenylate cyclase activator and inducer of intracellular cAMP formation[1].
Target Antigen
Adenylate Cyclase; Autophagy; FXR
Type
Reference compound
Related Pathways
Autophagy;GPCR/G Protein;Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Endocrinology; Metabolic Disease; Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
O=C1[C@@]2(O)[C@]([C@@H](OC(C)=O)[C@@H](O)[C@@]3([H])C(C)(C)CC[C@H](O)[C@@]32C)(C)O[C@@](C)(C=C)C1
Molecular Weight
410.50
References & Citations
[1]Li X, et al. Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 2015;17(2):195-203. |[2]Guan J et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature. 2022;605(7909):325-331. |[3]Wang H, et al. Small molecules enable cardiac reprogramming of mouse fibroblasts with a single factor, Oct4. Cell Rep. 2014 Mar 13;6(5):951-|[4]Bar-Nur O, et al. Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors. Stem Cell Reports. 2018 May 8;10(5):1505-1521. |[5]Zhao J, et al. Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates. Nat Med. 2022 Feb;28(2):272-282.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
CAS Number
66575-29-9
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