BTK-IN-25

BTK-IN-25 (Compound 71) is a BTK inhibitor (IC50: 0.77 nM) . BTK-IN-25 inhibits the proliferation of DOHH2 cells (IC50: 1 nM) [1].

Product Specifications

CAS Number

[2562351-92-0]

UNSPSC

12352005

Target

Btk

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/btk-in-25.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C=C(C=C1)OC2=C(C=CC=C2)F)F)C3=CNC4=NC=C(OCC)C(N[C@@H]5CC[C@H](OC5)CO)=C34

Molecular Formula

C28H27F2N3O5

Molecular Weight

523.53

References & Citations

[1]Tan H, et al. Substituted pyrrolo[2,3-b]pyridine and pyrazolo[3,4-b]pyridine derivatives as protein kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cell proliferative disorders. World Intellectual Property Organization, WO2020239124 A1. 2020-12-03.|[2]Tan Haohan. Substituted pyrrolo [2,3-b ] pyridine and pyrazolo [3,4-b ] pyridine derivatives as protein kinase inhibitors. Patent. CN114008042.