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CDK4/6-IN-17

CDK4/6-IN-17 (Compound 12) is a CDK4/6 inhibitor (IC50: 50: 10-100 nM) . CDK4/6-IN-17 inhibits tumor growth in COLO205 xenograft tumors[1].

Product Specifications

CAS Number

2035069-96-4

UNSPSC

12352005

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk4-6-in-17.html

Solubility

10 mM in DMSO

Smiles

FC([C@H]1N2C3=CC(C4=NC(NC5=CC=C(C=N5)CN6CCN(CC6)CC)=NC=C4F)=CC(F)=C3N=C2CC1)F

Molecular Formula

C27H28F4N8

Molecular Weight

540.56

References & Citations

[1]Zhao X, et al. Preparation of benzopyrroloimidazolyl compounds as CDK4/6 kinase inhibitors. World Intellectual Property Organization, WO2016173505 A1. 2016-11-03.|[2]Zhao Xingdong. A kind of kinase inhibitor. Patent. CN107849012.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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