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SHP2-IN-14

SHP2-IN-14 (Compound 27) is a SHP2 allosteric inhibitor (IC50: 7 nM) . SHP2-IN-14 has high blood concentration and area under the curve, and has good pharmacokinetic property[1].

Product Specifications

CAS Number

[2673400-91-2]

UNSPSC

12352005

Target

SHP2

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/shp2-in-14.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C2C(C3=C(Cl)C(Cl)=NC=C3)=NNC2=NC(N4CCC(C5=CC=CC=C5)(N)CC4)=N1)N

Molecular Formula

C22H20Cl2N8O

Molecular Weight

483.35

References & Citations

[1]Huang X, et al. Preparation of heteroaryl derivatives as antitumor agents. World Intellectual Property Organization, WO2021143680 A1 2021-07-22.|[2]Huang, Xiangui. Heteroaryl derivative and preparation method and application thereof. Patent. CN114867720.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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