SHP2-IN-14
Product Specifications
UNSPSC Description
SHP2-IN-14 (Compound 27) is a SHP2 allosteric inhibitor (IC50: 7 nM). SHP2-IN-14 has high blood concentration and area under the curve, and has good pharmacokinetic property[1].
Target Antigen
SHP2
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shp2-in-14.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C2C(C3=C(Cl)C(Cl)=NC=C3)=NNC2=NC(N4CCC(C5=CC=CC=C5)(N)CC4)=N1)N
Molecular Weight
483.35
References & Citations
[1]Huang X, et al. Preparation of heteroaryl derivatives as antitumor agents. World Intellectual Property Organization, WO2021143680 A1 2021-07-22.|[2]Huang, Xiangui. Heteroaryl derivative and preparation method and application thereof. Patent. CN114867720.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153699/SHP2-IN-14-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153699/
Clinical Information
No Development Reported
CAS Number
2673400-91-2
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