SORT-PGRN interaction inhibitor 2
SORT-PGRN interaction inhibitor 2 is a SORT-PGRN inhibitor that can decreases SORT1 protein expression and increases extracellular PGRN secretion in mammalian cell lines. SORT-PGRN interaction inhibitor 2 can be used for neurological disease research[1].
Product Specifications
CAS Number
1008233-79-1
UNSPSC
12352005
Hazard Statement
H315-H318-H335
Target
Neurotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sort-pgrn-interaction-inhibitor-2.html
Solubility
10 mM in DMSO
Smiles
CC1CN(CCOC2=CC(C)=CC=C2C(C)(C)C)CCC1
Molecular Formula
C19H31NO
Molecular Weight
289.46
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501
References & Citations
[1]Lee WC, et.al. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Hum Mol Genet. 2014 Mar 15;23 (6) :1467-78.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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