SORT-PGRN interaction inhibitor 2

SORT-PGRN interaction inhibitor 2 is a SORT-PGRN inhibitor that can decreases SORT1 protein expression and increases extracellular PGRN secretion in mammalian cell lines. SORT-PGRN interaction inhibitor 2 can be used for neurological disease research[1].

Product Specifications

CAS Number

[1008233-79-1]

UNSPSC

12352005

Hazard Statement

H315-H318-H335

Target

Neurotensin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sort-pgrn-interaction-inhibitor-2.html

Solubility

10 mM in DMSO

Smiles

CC1CN(CCOC2=CC(C)=CC=C2C(C)(C)C)CCC1

Molecular Formula

C19H31NO

Molecular Weight

289.46

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Lee WC, et.al. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Hum Mol Genet. 2014 Mar 15;23 (6) :1467-78.