PROTAC IRAK4 degrader-8
PROTAC IRAK4 degrader-8 (Compound 2) is a PROTAC IRAK4 degrader (IC50: 15.5 nM) . PROTAC IRAK4 degrader-8 degrades IRAK4 in THP-1 cells (DC50: 1.8 nM) 。PROTAC IRAK4 degrader-8 also inhibits L-6 production in human whole blood and LPS-induced human PBMC cells, with IC50s of 246 nM and 2.2 nM respectively[1].
Product Specifications
CAS Number
2911615-06-8
UNSPSC
12352005
Target
IRAK; PROTACs
Type
Reference compound
Related Pathways
Immunology/Inflammation; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-irak4-degrader-8.html
Solubility
10 mM in DMSO
Smiles
O=C(C(C=C1)=CC(N(CCC2=O)C(N2)=O)=C1Cl)N3CCC(CCN4C[C@H]5CC[C@H](N(N=C6C(F)F)C=C6NC(C7=C(N=C(N8[C@](CO9)([H])C[C@]9([H])C8)C=C%10)N%10N=C7)=O)CC5)(CC4)CC3
Molecular Formula
C43H50ClF2N11O5
Molecular Weight
874.38
References & Citations
[1]Ye Z, et al. Preparation of (pyrazolyl) pyrazolo[1,5-a]pyrimidinyl carboxamide derivatives as IRAK4 degrading agents and its applications. China, CN115710274 A. 2023-02-24.|[2]Ye Zhengqing. IRAK4 degradation agent, preparation method and application thereof. Patent. CN115710274.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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