TH-Z827
TH-Z827 is a mutant selective KRAS (G12D) inhibitor with an IC50 of 2.4 μM. TH-Z827 does not bind KRAS (WT) or KRAS (G12C) . TH-Z827 blocked the KRAS (G12D) -CRAF interaction with an IC50 value of 42 μM[1].
Product Specifications
CAS Number
[2847881-81-4]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/th-z827.html
Purity
95.12
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(CCC1)[C@@H]1COC2=NC(N3[C@@H]4CNC[C@H]3CC4)=C5C(CN(C6=CC=CC7=C6C(C)=CC=C7)CC5)=N2
Molecular Formula
C30H38N6O
Molecular Weight
498.66
References & Citations
[1]Zhongwei Mao, et al. KRAS (G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov. 2022 Jan 25;8 (1) :5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Available Sizes
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