TH-Z816
TH-Z816 is a reversible inhibitor againstKRAS (G12D) mutation with an IC50 value of 14 μM, which can be used in cancer research[1].
Product Specifications
CAS Number
2847881-42-7
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/th-z816.html
Solubility
10 mM in DMSO
Smiles
C[C@H]1N(CCNC1)C2=C3C(CN(C4=CC=CC5=C4C(C)=CC=C5)CC3)=NC(OC[C@H]6N(CCC6)C)=N2
Molecular Formula
C29H38N6O
Molecular Weight
486.65
References & Citations
[1]Zhongwei Mao, et al. KRAS (G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov. 2022 Jan 25;8 (1) :5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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