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TH-Z816

TH-Z816 is a reversible inhibitor againstKRAS (G12D) mutation with an IC50 value of 14 μM, which can be used in cancer research[1].

Product Specifications

CAS Number

2847881-42-7

UNSPSC

12352005

Target

Ras

Type

Reference compound

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/th-z816.html

Solubility

10 mM in DMSO

Smiles

C[C@H]1N(CCNC1)C2=C3C(CN(C4=CC=CC5=C4C(C)=CC=C5)CC3)=NC(OC[C@H]6N(CCC6)C)=N2

Molecular Formula

C29H38N6O

Molecular Weight

486.65

References & Citations

[1]Zhongwei Mao, et al. KRAS (G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov. 2022 Jan 25;8 (1) :5.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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