Bivamelagon (hydrochloride)
Bivamelagon (MC-4R Agonist 2) hydrochloride is an orally active and BBB-penetrable MC4R agonist with EC50 values of 0.562 nM (Luci assay) and 36.5 nM (cAMP assay), and a Ki of 65 nM. Bivamelagon hydrochloride can be used for the research of diseases such as obesity and diabetes[1].
Product Specifications
CAS Number
[2641595-55-1]
Product Name Alternative
MC-4R Agonist 2 (hydrochloride)
UNSPSC
12352005
Target
Melanocortin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bivamelagon-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1[C@H](C2=CC=C(C=C2)Cl)CN(C1)C(C)(C)C)N3[C@@H](C[C@@H](C3)N([C@@H]4CC[C@@H](CC4)C)C(C(C)C)=O)C(N5CCOCC5)=O.[H]Cl
Molecular Formula
C35H54Cl2N4O4
Molecular Weight
665.73
References & Citations
[1]Seung Wan Kang, et al. Melanocortin-4 receptor agonists. Patent WO2021091283A1. 2021-05-14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MC4R
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