HDAC8-IN-4
HDAC8-IN-4 is a selective inhibitor of HDAC8. HDAC8-IN-4 inhibits HDAC8 and HDAC3 with IC50s of 0.15 and 12 μM[1].
Product Specifications
CAS Number
[1600528-05-9]
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac8-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC(C2=CSC(CSC3=CC=CC=C3)=N2)=C1)NO
Molecular Formula
C17H14N2O2S2
Molecular Weight
342.44
References & Citations
[1]Suzuki T, et al. Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylase 8-selective inhibitors. ChemMedChem. 2014 Mar;9 (3) :657-64.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC3; HDAC8
Curated Selection
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