BI01826025

BI01826025 (pArg-JQ1) is a bromodomain1 of BRDT (BRDTBD1) PROTAC degrader. BI01826025 can be used for testing the regulatory effect of ClpC2 on the ClpC1P1P2 protease[1].

Product Specifications

Product Name Alternative

PArg-JQ1

UNSPSC

12352005

Target

Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/bi01826025.html

Solubility

10 mM in DMSO

Smiles

CC(N[C@@H](CCCNC(NP(O)(O)=O)=N)C(NCCOCCNC(C[C@H]1C2=NN=C(C)N2C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N1)=O)=O)=O

Molecular Formula

C31H42ClN10O7PS

Molecular Weight

765.22

References & Citations

[1]Hoi DM, et al. Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival. Cell. 2023 May 11;186 (10) :2176-2192.e22.|[2]Hoi DM, et al. Clp-targeting BacPROTACs impair mycobacterial proteostasis and survival. Cell. 2023 May 11;186 (10) :2176-2192.e22.