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TLR7/8 agonist 8

TLR7/8 agonist 8 (compound 24m) is a potent toll-like receptor 7/8 (TLR7/8) dual agonist, with EC50s of 27 and 12 nM for hTLR7 and hTLR8, respectively. TLR7/8 agonist 8 can improve the antitumor activity of PD-1/PD-L1 blockade[1].

Product Specifications

CAS Number

2649170-16-9

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tlr7-8-agonist-8.html

Purity

98.69

Solubility

10 mM in DMSO

Smiles

CCCCNC1=C2N=C(CC3=CC=C(CN4CC5(C4)COC5)C=C3)C=CC2=NC(N)=N1

Molecular Formula

C24H30N6O

Molecular Weight

418.53

References & Citations

[1]Wang Z, et, al. Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy. J Med Chem. 2021 Jun 10;64 (11) :7507-7532.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TLR7; TLR8

Available Sizes

Frequently Asked Questions

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