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AP-C1

AP-C1 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP) -dependent protein kinase II (cGKII) with a pIC50 of 6.5. AP-C1 only weakly inhibits cGKII-dependent anion secretion[1].

Product Specifications

CAS Number

2234280-26-1

UNSPSC

12352005

Target

PKG

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ap-c1.html

Solubility

10 mM in DMSO

Smiles

COC(C(OC)=C1)=CC=C1CCNC2=NC=CC(C3=CC4=C(C=CC=C4)C=C3)=N2

Molecular Formula

C24H23N3O2

Molecular Weight

385.46

References & Citations

[1]Marcel J C Bijvelds, et al. Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J Biol Chem. 2018 May 25;293 (21) :8173-8181.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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