PROTAC BTK Degrader-3
PROTAC BTK Degrader-3 is a potent BTK degrader with a DC50 value of 10.9 nM of BTK degradation in Mino cells. PROTAC BTK Degrader-3 has the potential for B-cell malignancies, including chronic lymphoid malignancies research[1].
Product Specifications
CAS Number
[2563861-90-3]
UNSPSC
12352005
Target
Btk; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-btk-degrader-3.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=CC=C(N3CC(C3)N4CC(C4)N5CCC(CC5)N6N=C(C7=C6N=CN=C7N)C8=CC=C(OC9=CC=CC=C9)C=C8)C=C2C(N1C%10C(NC(CC%10)=O)=O)=O
Molecular Formula
C41H40N10O5
Molecular Weight
752.82
References & Citations
[1]Zhangchen, et al. Salt of compound for degrading btk, crystal form thereof, and use thereof in medicine. Patent WO2022052950A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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CD18 (Beta 2 Antigen CD18 (p95), Cell Surface Adhesion Glycoproteins LFA 1/CR3/p150 95 beta Subunit, Complement Receptor C3 beta Subunit, Integrin beta 2, ITGB2, LAD, LCAMB, Leukocyte Cell Adhesion Molecule CD18, LFA1, Lymphocyte Function Associated Antigen 1, Macrophage Antigen 1 (mac1) beta Subunit, MF17) (APC)
