PI5P4Ks-IN-3
PI5P4Ks-IN-3 (compound 30) is a covalent inhibitor of PI5P4K with IC50s of 1.34 μM (PI5P4Kα), and 9.9 μM (PI5P4Kβ), respectively. PI5P4Ks-IN-3 shows weak cellular activity[1].
Product Specifications
CAS Number
[2471969-07-8]
UNSPSC
12352005
Target
PI5P4K
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi5p4ks-in-3.html
Solubility
10 mM in DMSO
Smiles
CC(C=C1)=CC=C1N2C3=NC=NC(NC4=CC(NC(C5=CC=C(C=C5)NC(/C=C/CN(C)C)=O)=O)=CC=C4)=C3C=C2
Molecular Formula
C32H31N7O2
Molecular Weight
545.63
References & Citations
[1]Manz TD, et al. Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. ACS Med Chem Lett. 2019 Nov 3;11 (3) :346-352.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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