PI5P4Ks-IN-3

PI5P4Ks-IN-3 (compound 30) is a covalent inhibitor of PI5P4K with IC50s of 1.34 μM (PI5P4Kα), and 9.9 μM (PI5P4Kβ), respectively. PI5P4Ks-IN-3 shows weak cellular activity[1].

Product Specifications

CAS Number

[2471969-07-8]

UNSPSC

12352005

Target

PI5P4K

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pi5p4ks-in-3.html

Solubility

10 mM in DMSO

Smiles

CC(C=C1)=CC=C1N2C3=NC=NC(NC4=CC(NC(C5=CC=C(C=C5)NC(/C=C/CN(C)C)=O)=O)=CC=C4)=C3C=C2

Molecular Formula

C32H31N7O2

Molecular Weight

545.63

References & Citations

[1]Manz TD, et al. Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. ACS Med Chem Lett. 2019 Nov 3;11 (3) :346-352.