Prexigebersen
Prexigebersen is an antisense oligonucleotide designed to inhibit protein synthesis of Grb2 (growth factor receptor bound protein 2) .
Product Specifications
CAS Number
202484-91-1
Product Name Alternative
BP1001
UNSPSC
12352208
Target
ERK
Type
Oligonucleotides
Related Pathways
MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/prexigebersen.html
Solubility
10 mM in H2O
Smiles
[Prexigebersen]
Molecular Formula
C177H224N63O110P17
Molecular Weight
5520.57
References & Citations
[1]Maro Ohanian, Tara L. Lin, Ellen Ritchie, et al. Pierce, Ana Tari Ashizawa, Hagop Kantarjian, Jorge E. Cortes, Gail J. Roboz; Safety and Efficacy of Lower Intensity Induction Therapy with Intravenous Prexigebersen (BP1001) in Patients with High-Risk and Relapsed/Refractory Acute Myeloid Leukemia (AML) . Blood 2021; 138 (Supplement 1) : 1281.|[2]Tremblay G, Khalafaghian G, Legault J, Nielsen P, Bartlett A. Dual ligation hybridization assay for the specific determination of oligonucleotide therapeutics. Bioanalysis. 2011;3 (5) :499-508.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
Phase 2
Frequently Asked Questions
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