Rosomidnar (sodium)
PNT100 sodium is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death.
Product Specifications
Product Name Alternative
PNT100 (sodium)
UNSPSC
12352208
Target
Bcl-2 Family
Type
Oligonucleotides
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rosomidnar-sodium.html
Solubility
10 mM in H2O
Smiles
[Rosomidnar(sodium)]
Molecular Formula
C227H267N88Na24O141P23
Molecular Weight
7221 (free acid)
References & Citations
[1]Rodrigueza WV, Woolliscroft MJ, Ebrahim AS, et al. Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide. Cancer Chemother Pharmacol. 2014;74 (1) :151-166.|[2]Westin J, Maris MB, Jacobson CA, et al. Safety and Efficacy of a DNA Oligonucleotide Therapy in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma. Clin Lymphoma Myeloma Leuk. 2022;22 (1) :52-59.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Frequently Asked Questions
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