PF-04523655 (sodium)

PF-04523655 sodium is a siRNA directed against RTP801 gene. RTP801 sodium is an inhibitor of the mammalian target of rampamycin complex 1 (mTORC1) and downstream transcription factor HIF-1.

Product Specifications

UNSPSC

12352208

Target

Small Interfering RNA (siRNA)

Type

Oligonucleotides

Related Pathways

Epigenetics

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pf-04523655-sodium.html

Purity

98.71

Solubility

10 mM in H2O

Smiles

[PF-04523655(sodium)]

References & Citations

[1]Rittenhouse KD, Johnson TR, Vicini P, et al. RTP801 gene expression is differentially upregulated in retinopathy and is silenced by PF-04523655, a 19-Mer siRNA directed against RTP801. Invest Ophthalmol Vis Sci. 2014;55 (3) :1232-1240.|[2]Nguyen QD, Schachar RA, Nduaka CI, et al. Evaluation of the siRNA PF-04523655 versus ranibizumab for the treatment of neovascular age-related macular degeneration (MONET Study) . Ophthalmology. 2012;119 (9) :1867-1873.