Olezarsen (sodium)

Olezarsen sodium is an N-acetyl-galactosamine-conjugated antisense oligonucleotide targeted to hepatic APOC3 mRNA to inhibit apolipoprotein C-III (apoC-III) production, in lowering triglyceride levels in patients at high risk for or with established cardiovascular disease.

Product Specifications

CAS Number

[2298451-31-5]

Product Name Alternative

ISIS 678354 (sodium) ; IONIS-APOCIII-LRx (sodium) ; AKCEA-APOCIII-LRx (sodium)

UNSPSC

12352208

Target

Apolipoprotein

Type

Oligonucleotides

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/olezarsen-sodium.html

Purity

96.53

Solubility

10 mM in H2O

Smiles

[Olezarsen(sodium)]

Molecular Formula

C296H419N71Na20O154P20S19

Molecular Weight

8684.86 (free acid)

References & Citations

[1]Tardif JC, Karwatowska-Prokopczuk E, Amour ES, et al. Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk. Eur Heart J. 2022;43 (14) :1401-1412.|[2]Karwatowska-Prokopczuk E, Tardif JC, Gaudet D, et al. Effect of olezarsen targeting APOC-III on lipoprotein size and particle number measured by NMR in patients with hypertriglyceridemia. J Clin Lipidol. 2022;16 (5) :617-625.