Olezarsen
Olezarsen is an N-acetyl-galactosamine-conjugated antisense oligonucleotide targeted to hepatic APOC3 mRNA to inhibit apolipoprotein C-III (apoC-III) production, in lowering triglyceride levels in patients at high risk for or with established cardiovascular disease.
Product Specifications
CAS Number
2097587-83-0
Product Name Alternative
ISIS 678354; IONIS-APOCIII-LRx; AKCEA-APOCIII-LRx
UNSPSC
12352208
Target
Apolipoprotein
Type
Oligonucleotides
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/olezarsen.html
Purity
96.53
Solubility
10 mM in H2O
Smiles
[Olezarsen]
Molecular Formula
C296H439N71O154P20S19
Molecular Weight
8684.86
References & Citations
[1]Tardif JC, Karwatowska-Prokopczuk E, Amour ES, et al. Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk. Eur Heart J. 2022;43 (14) :1401-1412.|[2]Karwatowska-Prokopczuk E, Tardif JC, Gaudet D, et al. Effect of olezarsen targeting APOC-III on lipoprotein size and particle number measured by NMR in patients with hypertriglyceridemia. J Clin Lipidol. 2022;16 (5) :617-625.|[3]Tomlinson B, et al. Advances in Dyslipidaemia Treatments: Focusing on ApoC3 and ANGPTL3 Inhibitors. J Lipid Atheroscler. 2024 Jan;13 (1) :2-20.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Launched
Isoform
ApoC3
Available Sizes
Frequently Asked Questions
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