Olezarsen

Olezarsen is an N-acetyl-galactosamine-conjugated antisense oligonucleotide targeted to hepatic APOC3 mRNA to inhibit apolipoprotein C-III (apoC-III) production, in lowering triglyceride levels in patients at high risk for or with established cardiovascular disease.

Product Specifications

CAS Number

[2097587-83-0]

Product Name Alternative

ISIS 678354; IONIS-APOCIII-LRx; AKCEA-APOCIII-LRx

UNSPSC

12352208

Target

Apolipoprotein

Type

Oligonucleotides

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/olezarsen.html

Purity

96.53

Solubility

10 mM in H2O

Smiles

[Olezarsen]

Molecular Formula

C296H439N71O154P20S19

Molecular Weight

8684.86

References & Citations

[1]Tardif JC, Karwatowska-Prokopczuk E, Amour ES, et al. Apolipoprotein C-III reduction in subjects with moderate hypertriglyceridaemia and at high cardiovascular risk. Eur Heart J. 2022;43 (14) :1401-1412.|[2]Karwatowska-Prokopczuk E, Tardif JC, Gaudet D, et al. Effect of olezarsen targeting APOC-III on lipoprotein size and particle number measured by NMR in patients with hypertriglyceridemia. J Clin Lipidol. 2022;16 (5) :617-625.|[3]Tomlinson B, et al. Advances in Dyslipidaemia Treatments: Focusing on ApoC3 and ANGPTL3 Inhibitors. J Lipid Atheroscler. 2024 Jan;13 (1) :2-20.