ISIS 329993 (sodium)

ISIS 329993 sodium is an antisense oligonucleotide targeting to C-reactive protein (CRP) . ISIS-CRPRx sodium has been tested in a rodent model of rheumatoid arthritis (RA) and was shown to improve the clinical signs of arthritis

Product Specifications

Product Name Alternative

ISIS-CRPRx (sodium)

UNSPSC

12352208

Target

C-type Lectin-like Receptors (CTLRs)

Type

Oligonucleotides

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/isis-329993-sodium.html

Solubility

10 mM in H2O

Smiles

[ISIS329993(sodium)]

References & Citations

[1]Warren MS, Hughes SG, Singleton W, Yamashita M, Genovese MC. Results of a proof of concept, double-blind, randomized trial of a second generation antisense oligonucleotide targeting high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis. Arthritis Res Ther. 2015;17 (1) :80. |[2]Noveck R, Stroes ES, Flaim JD, et al. Effects of an antisense oligonucleotide inhibitor of C-reactive protein synthesis on the endotoxin challenge response in healthy human male volunteers. J Am Heart Assoc. 2014;3 (4) :e001084.