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Cimdelirsen (sodium)

Cimdelirsen is a novel, ligand-conjugated, hepatic-targeted investigative antisense oligonucleotide designed to reduce growth hormone receptor (GHr) synthesis, thereby inhibiting deleterious effects of growth hormone (GH) hypersecretion and reducing circulating insulin-like growth factor-1 (IGF-1) levels in acromegaly patients.

Product Specifications

CAS Number

2131025-83-5

Product Name Alternative

ISIS 766720 (sodium) ; IONIS-GHR-LRx (sodium)

UNSPSC

12352208

Target

GHR; Small Interfering RNA (siRNA)

Type

Oligonucleotides

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/cimdelirsen-sodium.html

Solubility

10 mM in H2O

Smiles

[Cimdelirsen(sodium)]

Molecular Formula

C296H415N83Na20O152P20S15

Molecular Weight

8688.55 (free acid)

References & Citations

[1]Bhanot S, Fleseriu M, Geary R, et al. OR27-4 Placebo-Controlled and Open-Label Extension Study of a Novel Hepatic-Targeted Antisense Cimdelirsen (IONIS-GHR-LRx) Under Investigation in Acromegaly Patients. J Endocr Soc. 2022;6 (Suppl 1) :A526.

Shipping Conditions

Room temperature

Scientific Category

Oligonucleotides

Clinical Information

Phase 2

Frequently Asked Questions

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