ARC19499

ARC19499 is an aptamer that inhibits tissue factor pathway inhibitor (TFPI), thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

Product Specifications

CAS Number

[1350667-54-7]

Product Name Alternative

BAX499

UNSPSC

12352208

Target

Factor VIIa; Factor Xa; Tissue Factor Pathway Inhibitor (TFPI)

Type

Oligonucleotides

Related Pathways

Cytoskeleton; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/arc19499.html

Purity

93.65

Solubility

H2O : ≥ 100 mg/mL

Smiles

[ARC19499]

Molecular Weight

11078.95

References & Citations

[1]Waters EK, Genga RM, Schwartz MC, et al. Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor. Blood. 2011;117 (20) :5514-5522.|[2]Gissel M, Orfeo T, Foley JH, Butenas S. Effect of BAX499 aptamer on tissue factor pathway inhibitor function and thrombin generation in models of hemophilia. Thromb Res. 2012;130 (6) :948-955.