IRE1α kinase-IN-8
IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, is a potent IRE-1α inhibitor. IRE1α kinase-IN-8 can be used for research in diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) [1].
Product Specifications
CAS Number
[1338933-29-1]
UNSPSC
12352005
Target
IRE1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ire1α-kinase-in-8.html
Solubility
10 mM in DMSO
Smiles
O=CC1=C(OC(C(C2=CC=C(C(N3CCN(CC3)C)=O)C=C2)=C4C)=O)C4=CC=C1O
Molecular Formula
C23H22N2O5
Molecular Weight
406.43
References & Citations
[1]Zeng QP, et al. Benzoheterocyclecarboxaldehyde derivatives as IRE-1α inhibitors and their preparation and use for the treatment of diseases. World Intellectual Property Organization, WO2011127070 A2. 2011-10-13.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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