IRE1α kinase-IN-8

IRE1α kinase-IN-8, a benzoheterocyclecarboxaldehyde derivative, is a potent IRE-1α inhibitor. IRE1α kinase-IN-8 can be used for research in diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) [1].

Product Specifications

CAS Number

[1338933-29-1]

UNSPSC

12352005

Target

IRE1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ire1α-kinase-in-8.html

Solubility

10 mM in DMSO

Smiles

O=CC1=C(OC(C(C2=CC=C(C(N3CCN(CC3)C)=O)C=C2)=C4C)=O)C4=CC=C1O

Molecular Formula

C23H22N2O5

Molecular Weight

406.43

References & Citations

[1]Zeng QP, et al. Benzoheterocyclecarboxaldehyde derivatives as IRE-1α inhibitors and their preparation and use for the treatment of diseases. World Intellectual Property Organization, WO2011127070 A2. 2011-10-13.