Polfurmetinib (hydrate)
Polfurmetinib (MEK-IN-6) hydrate (compound 69) is a MEK inhibitor. Polfurmetinib hydrate has an IC50 of 2 nM for A375 cells[1].
Product Specifications
CAS Number
[2845153-35-5]
Product Name Alternative
MEK-IN-6 (hydrate)
UNSPSC
12352005
Target
MEK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mek-in-6-hydrate.html
Solubility
10 mM in DMSO
Smiles
O=C1C=C2C(C(N(CC2)OCCO)=O)=C(N1C)NC3=CC=C(C=C3F)SC.O
Molecular Formula
C18H22FN3O5S
Molecular Weight
411.45
References & Citations
[1]Shelley Allen, et al. 3,4-dihydro-2,7-naphthyridine-1,6 (2h,7h) -diones as mek inhibitors. WO2022208391A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MEK
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