PB830
PB830 (compound 41) is a potent receptor interacting protein 1 kinase (RIP1) Inhibitor with an IC50 of 50 of 1-100 nM in the cell necrosis assay[1].
Product Specifications
CAS Number
[2428401-23-2]
UNSPSC
12352005
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rip1-kinase-inhibitor-7.html
Solubility
DMSO : 66.67 mg/mL (ultrasonic; warming; heat to 160°C)
Smiles
O=C(N1CC(C1)CC2=CC(F)=CC=C2)N3N=CCC3C4=CC=CC=C4
Molecular Formula
C20H20FN3O
Molecular Weight
337.39
References & Citations
[1]Yaning SU, et al. Cyclic Ureas. WO2020103884A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1
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