RIP1 kinase inhibitor 5
RIP1 kinase inhibitor 5 (example 1) is a potent inhibitor of RIP1, which is used as a checkpoint kinase to control tumor immunity[1]. RIP1 kinase inhibitor 5 is similar with SIR1-365 (compound 13), which inhibits necrosis and iron death activity[2].
Product Specifications
CAS Number
2428422-17-5
UNSPSC
12352005
Target
Necroptosis; RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rip1-kinase-inhibitor-5.html
Solubility
10 mM in DMSO
Smiles
CCC(C)(C)C(N(CC1=CC(F)=CC(F)=C1)O)=O
Molecular Formula
C13H17F2NO2
Molecular Weight
257.28
References & Citations
[1]Su Yaning, et al. Preparation of cyrstalline forms of RIP1 inhibitor. World Intellectual Property Organization, WO2023066368 A1. 2023-04-27. |[2]Su Yaning, et al. Preparation of substituted amides as RIP1 inhibitors. World Intellectual Property Organization, WO2020103859 A1. 2020-05-28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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