RIP1 kinase inhibitor 4

RIP1 kinase inhibitor 4 (Example 3) is a BBB-penetrable RIP1 kinase inhibitor (EC50: [1]. RIP1 kinase inhibitor 4 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[2919836-00-1]

UNSPSC

12352005

Target

RIP kinase

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rip1-kinase-inhibitor-4.html

Solubility

10 mM in DMSO

Smiles

NC(N=C1)=NC=C1C#CC2CCC(C2)N3N=C4C(CCC4C5=CC=CC=C5)=C3

Molecular Formula

C23H23N5

Molecular Weight

369.46

References & Citations

[1]Su, Yaning, et al. Preparation of pyrazole and triazole heterocycle derivative as RIP1 kinase inhibitor. Patent. WO2023040870.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

RIPK1

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