PROTAC SMARCA2 degrader-1
PROTAC SMARCA2 degrader-1 (compound ex7) is a BRM2 (SMARCA2) degrader (DC50target protein ligand-linker conjugate[1].
Product Specifications
CAS Number
[2892523-73-6]
UNSPSC
12352005
Target
Target Protein Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-degrader-1.html
Solubility
10 mM in DMSO
Smiles
OC(C=CC=C1)=C1C2=NN=C(NC3)C(NC3(CCC4)CN4CC5CCN(CC5)CCOC6=NOC([C@@H](C(C)C)C(N7[C@@H](C[C@H](C7)O)C(N[C@H](C8=CC=C(C9=C(C)N=CS9)C=C8)C)=O)=O)=C6)=C2
Molecular Formula
C49H62N10O6S
Molecular Weight
919.14
References & Citations
[1]Lu Liang, et al. Preparation of pyridazine derivatives as BRM targeting compounds and E3 ubiquitin ligase binding agents for the treatment of cancers. World Intellectual Property Organization, WO2023287787 A1 2023-01-19.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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