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PROTAC SMARCA2 degrader-1

PROTAC SMARCA2 degrader-1 (compound ex7) is a BRM2 (SMARCA2) degrader (DC50target protein ligand-linker conjugate[1].

Product Specifications

CAS Number

[2892523-73-6]

UNSPSC

12352005

Target

Target Protein Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-smarca2-degrader-1.html

Solubility

10 mM in DMSO

Smiles

OC(C=CC=C1)=C1C2=NN=C(NC3)C(NC3(CCC4)CN4CC5CCN(CC5)CCOC6=NOC([C@@H](C(C)C)C(N7[C@@H](C[C@H](C7)O)C(N[C@H](C8=CC=C(C9=C(C)N=CS9)C=C8)C)=O)=O)=C6)=C2

Molecular Formula

C49H62N10O6S

Molecular Weight

919.14

References & Citations

[1]Lu Liang, et al. Preparation of pyridazine derivatives as BRM targeting compounds and E3 ubiquitin ligase binding agents for the treatment of cancers. World Intellectual Property Organization, WO2023287787 A1 2023-01-19.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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