Mcl-1 inhibitor 13

Mcl-1 inhibitor 13 (Example 9) is a MCL-1 inhibitor (Ki: 8.2 nM) . Mcl-1 inhibitor 13 can be used for the research of cancers[1].

Product Specifications

CAS Number

[2445466-06-6]

UNSPSC

12352005

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mcl-1-inhibitor-13.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=CC=C1C2=NC(COC3=C(C[C@H](C(O)=O)OC4=NC=NN5C4=[C@@]([C@@]6=C(C)C(Cl)=C(OCCN7CCN(C)CC7)C=C6)C(C8=CC=C(F)C=C8)=C5)C=CC=C3)=CC=N2

Molecular Formula

C47H45ClFN7O6

Molecular Weight

858.35

References & Citations

[1]Jincong Zhuo, et al. 2- ((5- (phenyl) -pyrrolo[2,1-f][1,2,4]triazin-4-yl) amino) -3- (phenyl) propanoic acid derivatives and related compounds as mcl-1 enzyme inhibitors for treating cancer. Patent WO2020123994.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Mcl-1

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