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(E/Z) -TG003

(E/Z) -TG003 is a racemic compound of (Z) -TG003 and (E) -TG003. (Z) -TG003 is a potent inhibitor of Clk1/Sty; inhibits Clk1 and Clk4 with IC50 values of 20 and 15 nM, respectively[1].

Product Specifications

CAS Number

300801-52-9

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

CDK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e-z-tg003.html

Solubility

10 mM in DMSO

Smiles

COC(C=C1N/2CC)=CC=C1SC2=C\C(C)=O

Molecular Formula

C13H15NO2S

Molecular Weight

249.33

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Muraki M, et al. Manipulation of alternative splicing by a newly developed inhibitor of Clks. J Biol Chem. 2004 Jun 4;279 (23) :24246-54.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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