A1/A3 AR antagonist 3

A1/A3 AR antagonist 3 is an A1R/A3R dual antagonist with high affinity at low-micromolar to low-nanomolar. A1/A3 AR antagonist 3 can be used for the research of chronic heart diseases[1].

Product Specifications

CAS Number

[2665804-57-7]

UNSPSC

12352005

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/a1-a3-ar-antagonist-3.html

Solubility

10 mM in DMSO

Smiles

N#CC1=CC2=C(NN=C2C3=CC=CC=C3)C(NC4=CC(OC)=C(C(OC)=C4)OC)=N1

Molecular Formula

C22H19N5O3

Molecular Weight

401.42

References & Citations

[1]Stampelou M, et al. Dual A1/A3 Adenosine Receptor Antagonists: Binding Kinetics and Structure-Activity Relationship Studies Using Mutagenesis and Alchemical Binding Free Energy Calculations. J Med Chem. 2022;65 (19) :13305-13327.