A1/A3 AR antagonist 3
A1/A3 AR antagonist 3 is an A1R/A3R dual antagonist with high affinity at low-micromolar to low-nanomolar. A1/A3 AR antagonist 3 can be used for the research of chronic heart diseases[1].
Product Specifications
CAS Number
[2665804-57-7]
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/a1-a3-ar-antagonist-3.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC2=C(NN=C2C3=CC=CC=C3)C(NC4=CC(OC)=C(C(OC)=C4)OC)=N1
Molecular Formula
C22H19N5O3
Molecular Weight
401.42
References & Citations
[1]Stampelou M, et al. Dual A1/A3 Adenosine Receptor Antagonists: Binding Kinetics and Structure-Activity Relationship Studies Using Mutagenesis and Alchemical Binding Free Energy Calculations. J Med Chem. 2022;65 (19) :13305-13327.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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