Tankyrase-IN-5

Tankyrase-IN-5 (Compound 30f), an analogue of MSC2504877 (HY-123851), is a tankyrase TNKS1 and TNKS2 inhibitor with IC50s of 2.3 nM and 7.9 nM, respectively[1].

Product Specifications

CAS Number

[1460285-69-1]

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tankyrase-in-5.html

Solubility

10 mM in DMSO

Smiles

O=C1NC(C2=CC=C(C(C)(C)O)C=C2)=CN3C=C(C)C=C13

Molecular Formula

C17H18N2O2

Molecular Weight

282.34

References & Citations

[1]Buchstaller HP, et al. Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models. J Med Chem. 2021 Jul 22;64 (14) :10371-10392.