Tankyrase-IN-5
Product Specifications
UNSPSC Description
Tankyrase-IN-5 (Compound 30f), an analogue of MSC2504877 (HY-123851), is a tankyrase TNKS1 and TNKS2 inhibitor with IC50s of 2.3 nM and 7.9 nM, respectively[1].
Target Antigen
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tankyrase-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(C2=CC=C(C(C)(C)O)C=C2)=CN3C=C(C)C=C13
Molecular Weight
282.34
References & Citations
[1]Buchstaller HP, et al. Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models. J Med Chem. 2021 Jul 22;64(14):10371-10392.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-153332/Tankyrase-IN-5-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-153332/
Clinical Information
No Development Reported
CAS Number
1460285-69-1
Curated Selection
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