Tankyrase-IN-5
Tankyrase-IN-5 (Compound 30f), an analogue of MSC2504877 (HY-123851), is a tankyrase TNKS1 and TNKS2 inhibitor with IC50s of 2.3 nM and 7.9 nM, respectively[1].
Product Specifications
CAS Number
[1460285-69-1]
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tankyrase-in-5.html
Solubility
10 mM in DMSO
Smiles
O=C1NC(C2=CC=C(C(C)(C)O)C=C2)=CN3C=C(C)C=C13
Molecular Formula
C17H18N2O2
Molecular Weight
282.34
References & Citations
[1]Buchstaller HP, et al. Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models. J Med Chem. 2021 Jul 22;64 (14) :10371-10392.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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