AZ-TAK1
AZ-TAK1, an ATP-competitive small molecule inhibitor of TAK1, dephosphorylates TAK1, p38, and IκB-α in lymphoma cell lines[1].
Product Specifications
CAS Number
1413440-36-4
UNSPSC
12352005
Target
MAP3K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/az-tak1.html
Solubility
10 mM in DMSO
Smiles
FC1=C(C2=CN=C3C=CC=NN32)N=C(NC4=CC(OCCN5CCC(CC5)O)=CC(CC)=C4)N=C1
Molecular Formula
C25H28FN7O2
Molecular Weight
477.53
References & Citations
[1]Daniela Buglio, et al. Essential role of TAK1 in regulating mantle cell lymphoma survival. Blood. 2012 Jul 12;120 (2) :347-55.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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