CaSR antagonist-1
CaSR antagonist-1 is a calcium sensing receptor (CaSR) antagonist with an IC50 value of 50 nM. CaSR antagonist-1 can be used for the research of disorders associated with abnormal bone or mineral homeostasis such as osteoporosis[1].
Product Specifications
CAS Number
1219811-83-2
UNSPSC
12352005
Target
CaSR
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/casr-antagonist-1.html
Solubility
10 mM in DMSO
Smiles
O=C1C(C2=CC(C3=CC=CC=N3)=C(C)S2)=C(C)N=C(N1CCC4=CC=CC=C4)C5=C(O)C(F)=CC=C5
Molecular Formula
C29H24FN3O2S
Molecular Weight
497.58
References & Citations
[1]Ramanjulu JM, et al. Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction. ACS Med Chem Lett. 2021 Aug 10;12 (9) :1396-1404.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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