LSN3160440

LSN3160440 is an allosteric modulator of GLP-1R, which acts as a protein-protein interaction (PPI) stabilizer or molecular glue to assist in the adhesion of inactive GLP-1 (9-36) NH2 on GLP-1R[1][2].

Product Specifications

CAS Number

[2765539-59-9]

UNSPSC

12352005

Target

GLP Receptor; Molecular Glues

Type

Reference compound

Related Pathways

GPCR/G Protein; PROTAC

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/lsn3160440.html

Purity

98.08

Solubility

10 mM in DMSO

Smiles

C[C@H](C1=C(C(OC)=CC=C1Cl)Cl)N2C3=CC(C4=C([C@H]5CCCCN5)C=CC=C4)=CC=C3N=C2

Molecular Formula

C27H27Cl2N3O

Molecular Weight

480.43

References & Citations

[1]Hui-Jun Liao, et al. Investigating Potential GLP-1 Receptor Agonists in Cyclopeptides from Pseudostellaria heterophylla, Linum usitatissimum, and Drymaria diandra, and Peptides Derived from Heterophyllin B for the Treatment of Type 2 Diabetes: An In Silico Study. Metabolites. 2022 Jun 15;12 (6) :549.|[2]Hongyu Wu, et al. Molecular glues modulate protein functions by inducing protein aggregation: A promising therapeutic strategy of small molecules for disease treatment. Acta Pharm Sin B. 2022 Sep;12 (9) :3548-3566.