TrkB-IN-1

TrkB-IN-1 is a potent and orally active TrkB agonist and has favorable PK properties. TrkB-IN-1 reverses the cognitive defects in an AD mouse model and can be used for alzheimer’s disease research[1].

Product Specifications

CAS Number

[1609067-49-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Trk Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/trkb-in-1.html

Purity

99.2

Solubility

10 mM in DMSO

Smiles

O=C1C=C(C2=CC=CC=C2)OC3=C(OC(NC)=O)C(OC(NC)=O)=CC=C13

Molecular Formula

C19H16N2O6

Molecular Weight

368.34

Precautions

H302, H315, H319, H335

References & Citations

[1]Chun Chen, et al. The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer's disease. Proc Natl Acad Sci U S A. 2018 Jan 16;115 (3) :578-583.