Anhydroleucovorin

Anhydroleucovorin is a form of tetrahydrofolate and is a substrate for cyclohydrolase, which converts it to 10-formyltetrahydrofolate. Anhydroleucovorin can be used for research in the field of tumors[1][2].

Product Specifications

CAS Number

[7444-29-3]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Drug Intermediate

Type

Reference compound

Related Pathways

Others

Field of Research

Others; Cancer

Assay Protocol

https://www.medchemexpress.com/anhydroleucovorin.html

Purity

96.60

Solubility

DMSO : 8.33 mg/mL (ultrasonic; adjust pH to 1 with 1 M HCL)

Smiles

O=C1C2=C(NC(N)=N1)NC[C@@]3([H])N2C=[N+](C4=CC=C(C=C4)C(N[C@H](C([O-])=O)CCC(O)=O)=O)C3

Molecular Formula

C20H21N7O6

Molecular Weight

455.42

Precautions

H315, H319

References & Citations

[1]M J OSBORN, et al. Participation of anhydroleucovorin in the hydroxymethyl tetrahydrofolic dehydrogenase system. Biochim Biophys Acta,1957,26, 3.|[2]K Motycka, et al. Localized chemotherapy of Gardner's lymphosarcoma of C3H mice using combinations of carrier-sorbed antifolics and detoxicating tetrahydrofolates. Czech Med,1981,4, 1.