7-Cyano-7-deaza-2'-deoxy guanosine
7-Cyano-7-deaza-2'-deoxy guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) [1].
Product Specifications
CAS Number
199859-58-0
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/7-cyano-7-deaza-2-deoxy-guanosine.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1C[C@H](N2C(NC(N)=NC3=O)=C3C(C#N)=C2)O[C@@H]1CO
Molecular Formula
C12H13N5O4
Molecular Weight
291.26
References & Citations
[1]Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100 (11) :6646-51.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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