2'-Deoxy-5'-O-DMT-N4-Fmoc-5-methylcytidine 3'-CE-phosphoramidite

2'-Deoxy-5'-O-DMT-N4-Fmoc-5-methylcytidine 3'-CE-phosphoramidite is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities[1].

Product Specifications

CAS Number

[176755-87-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

DNA/RNA Synthesis

Type

Oligonucleotides

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/2-deoxy-5-o-dmt-n4-fmoc-5-methylcytidine-3-ce-phosphoramidite.html

Solubility

10 mM in DMSO

Smiles

O=C1N=C(NC(OCC2C3=C(C=CC=C3)C4=C2C=CC=C4)=O)C(C)=CN1[C@H]5C[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](COC(C6=CC=CC=C6)(C7=CC=C(OC)C=C7)C8=CC=C(OC)C=C8)O5

Molecular Formula

C55H60N5O9P

Molecular Weight

966.07

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Gowher H, et al. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol Ther. 2004 Nov;3 (11) :1062-8.