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Mp-dLAE-PABC-MMAE

Mp-dLAE-PABC-MMAE is a agent-linker conjugate for ADC. mp-dLAE-PABC-MMAE contains a potent tubulin inhibitor Monomethyl auristatin E (HY-15162) . mp-dLAE-PABC-MMAE can be used to synthesis antibody-drug conjugates (ADCs) [1].

Product Specifications

CAS Number

[2625616-44-4]

UNSPSC

12352005

Target

Drug-Linker Conjugates for ADC

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mp-dlae-pabc-mmae.html

Purity

98.31

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N([C@H]([C@@H](CC(N1[C@H]([C@H](OC)[C@H](C(N[C@@H]([C@@H](O)C2=CC=CC=C2)C)=O)C)CCC1)=O)OC)[C@@H](C)CC)C)=O)=O)OCC3=CC=C(NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@@H](CC(C)C)NC(CCN4C(C=CC4=O)=O)=O)=O)=O)=O)C=C3

Molecular Formula

C68H102N10O17

Molecular Weight

1331.59

References & Citations

[1]Sandall Sharsti and Waight Andrew. Engineering of anti-CD228 antibodies and antibody-drug conjugates for cancer immunotherapy. WO2022031652. 2022.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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