5- (Trifluoromethyl) uridine
5- (Trifluoromethyl) uridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Product Specifications
CAS Number
[21618-67-7]
UNSPSC
12352005
Hazard Statement
H302-H315-H320-H335
Target
Nucleoside Antimetabolite/Analog
Type
Oligonucleotides
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/5-trifluoromethyl-uridine.html
Solubility
10 mM in DMSO
Smiles
O=C1N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C=C(C(N1)=O)C(F)(F)F
Molecular Formula
C10H11F3N2O6
Molecular Weight
312.20
Precautions
P264-P270-P330
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
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